Structural and functional connectivity in child psychiatric disorders

Completed

Conditions: Autism
autism spectrum disorder
10012562
ADHD
attention deficit hyperactivity disorder

Registration Number: NL-OMON39463

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 600

Inclusion Criteria

General inclusion criteria for all subject groups
• Aged 6 through 18 years at initial inclusion
• Ability to speak and comprehend Dutch (both participant and parent).;Inclusion criteria for subjects with autism
• DSM-IV (APA, 1994) diagnosis of autism, supported by ADI-R interview;Inclusion criteria for subjects with ADHD
• DSM-IV (APA, 1994) diagnosis of ADHD, supported by DISC interview ;Inclusion criteria for control subjects
• No DSM-IV (APA, 1994) diagnosis, supported by DISC interview
• No history of psychiatric illness in first degree family members of the subjects

Exclusion Criteria

1) Mental retardation (IQ < 70)
2) Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
3) Presence of metal objects in or around the body (pacemaker, dental braces)
4) History of or present neurological disorder

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoints of this study are developmental changes in structural and<br /><br>functional brain connectivity. The measures of interest are resting-state<br /><br>functional connectivity, as assessed with resting-state functional Magnetic<br /><br>Resonance Imaging (rs-fMRI), myelination as assessed with Magnetization<br /><br>Transfer Imaging (MTI), and white matter integrity, as assessed with<br /><br>track-based Diffusion Tensor Imaging (DTI)-measures.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>An exploratory analysis of the effect of genotype on shared risk genes for<br /><br>autism and ADHD will be conducted and symptoms of ADHD and ASD from symptom<br /><br>rating scales and performance on computerized tasks will be analyzed</p><br>