Structural and functional connectivity in relation to cognitive and social functioning of children with Neurofibromatosis Type 1
- Conditions
- Von Recklinghausen's DiseaseNF11004225810029299
- Registration Number
- NL-OMON32474
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
General inclusion criteria: age between 9 and 13 at time of study; Dutch speaking and signed informed consent from parents and participants. NF1 participants fulfill the diagnostic criteria specified by the National Institutes of Health Consensus Conference (National Institutes of Health, 1988), i.e. they meet two or more of the following criteria: six or more café-au-lait spots, two or more neurofibromas, skinfold freckling, an optic glioma, two or more Lisch nodules, or a first degree relative with NF1.
-history of psychiatric illness (other than ADHD), closed-head injury, endocrinological dysfunction, or neurological illness (other than NF1). Use of psychotropic medication (other than stimulants to treat ADHD-symptomatology). Many individuals with NF1 receive an ADHD-diagnosis (there are reports of an ADHD-incidence of up to 40-50% in NF1). Most of them will receive stimulant medication. Because of the high incidence we will not exclude individuals with an ADHD-diagnosis. Instead, we will control for ADHD and use of stimulant medication in our analyses.
-contraindications for fMRI
-premature birth
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Task performance, questionnaire data on social functioning, white matter<br /><br>integrity (i.e. Fractional Anisotropy (FA) measured with Diffusion Tensor<br /><br>Imaging (DTI) scan), T1-images to assess gray and white matter volumes<br /><br>(measured with structural anatomy scan), T2-images to assess activity (i.e.<br /><br>blood oxygen level dependent (BOLD) responses) during tasks (measured with<br /><br>functional MRI scans), and measures of functional connectivity between brain<br /><br>regions (cross-correlations), based on activity measured during the resting<br /><br>state scan and during task performance (i.e. using the fMRI-scans).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Performance and verbal IQ estimations as measured by Block Patterns and Word<br /><br>Knowledge from the WISC. Behavior data from the Child Behavior Checklist.</p><br>