Functional connectivity and neuronal networks in brain tumor patients with epilepsy

Completed

Conditions: brain tumor
Seizures
10029211
10039911

Registration Number: NL-OMON37154

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Inclusion criteria for glioma patients:
(1) adult (> 18 years)
(2) epilepsy (at least one epileptic seizure)
(3) histopathologically confirmed glioma or meningioma according to the WHO
(4) written informed consent.;Inclusion criteria for healthy controls
(1) adult (> 18 years)
(2) written informed consent;Inclusion criteria for language side-study (amendment):
(1) received intraoperative language mapping
(2) received resective brain surgery in the dominant hemisphere
(3) Dutch is native language

Exclusion Criteria

Exclusion criteria for glioma patients:
(1) psychiatric disease or symptoms
(2) insufficient mastery of the Dutch language
(3) inability to communicate adequately;Exclusion criteria for healthy controls:
(1) use of centrally acting drugs (including analgetics)
(2) psychiatric disease or symptoms
(3) disorders of the central nervous system
(4) insufficient mastery of the Dutch language

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- MEG-measures:<br /><br>clustercoefficient<br /><br>padlength<br /><br>synchronisation likelihood<br /><br><br /><br>- epilepsy diary (frequency and severity) and epilepsy burden<br /><br><br /><br>Language-study<br /><br>The main study parameters are an extensive language task, a naming task and a<br /><br>language performance questionnaire assessing functional outcome in patients who<br /><br>received resective brain surgery after intraoperative language mapping. The<br /><br>language task will measure language performance in various domains, e.g.<br /><br>speaking, listening, reading and writing, whereas the questionnaire will obtain<br /><br>information on how patients perceive their own language performance. The naming<br /><br>task will measure performance pre and post operatively. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>cognition<br /><br><br /><br>Language-study<br /><br>The secondary study parameters are the neuropsychological tests obtained pre-<br /><br>and postoperatively by a neuropsychologist. </p><br>