The Effect of Music Periodicity on Interictal Epileptiform Discharges

Not Applicable

Completed

• Conditions: Rolandic Epilepsy; Benign Childhood Epilepsy With Centrotemporal Spikes; Epilepsy; Seizures
• Interventions: Other: Mozart alternating with Beethoven; Other: Beethoven alternating with Mozart

• Registration Number: NCT01515436
• Lead Sponsor: Medical University of South Carolina

Brief Summary

The purpose of this study is to determine if having children listen to the music of Wolfgang Amadeus Mozart (Sonata for Two Pianos in D Major, K. 448) will lessen the amount of spike discharges on his/her Electroencephalography (EEG). These spike discharges often occur during a 24 hour period in the EEG of a child with Benign Childhood Epilepsy with Centrotemporal Spikes (BCECTS), or Rolandic Epilepsy. Should there be a decrease in the amount of spike discharges after listening to Mozart's music, this information may lead to new understanding and possible treatments for epilepsy.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-02
• Primary Completion: 2004-05
• Study Completion: 2007-12
• Status Verified: 2012-01
• Study First Submitted: 2012-01-18
• Study First Submitted QC: 2012-01-23
• Last Update Submitted: 2012-01-23
• Study First Posted: 2012-01-24
• Last Update Posted: 2012-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Female or male with BCECTS clinical history, and at least one seizure, as defined by the International League Against Epilepsy.
• EEG consistent with features of BCECTS: centrotemporal (rolandic) interictal spike discharges (ISDs) with otherwise normal background interictal EEG
• Screening neurological examination normal (by PI or other pediatric neurologist in the Division of Pediatric Neurology at MUSC)
• Age 5-12 years, inclusive
• On less than or equal to 2 anti-epileptic drugs (AED) [Range 0-2 AEDs]

Exclusion Criteria

• Currently taking Clonazepam or other Benzodiazepines
• Inability to complete 12 hour admission and comply with study protocol
• Prohibited Therapy or Activities During Study Period: Use of computer or video games. Viewing of video tapes will be prohibited due to potential effect of music in videos on underlying process of study.
• Due to the confounding factor of probably suppression of IEDs after a clinical seizure, any subject experiencing a seizure of any duration 24 hours prior to beginning the study will be excluded from the study.
• For any subject experiencing a seizure during the study, data analysis will cease from that point onward.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mozart alternating with Beethoven	Mozart alternating with Beethoven	Study participants will listen to Mozart's Sonata for Two Pianos in D Major, K. 448 alternating with Beethoven's Fur Elise.
Beethoven alternating with Mozart	Beethoven alternating with Mozart	Study participants will listen to Beethoven's Fur Elise alternating with Mozart's Sonata for Two Pianos in D Major, K. 448.

Trial Locations

Locations (1)

Medical University of South Carolina; 🇺🇸 Charleston, South Carolina, United States