Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus
Not Applicable
Completed
- Conditions
- Keratoconus
- Registration Number
- NCT02189447
- Lead Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
- Brief Summary
Evaluation of the safety and efficacy of surface ablation followed by Collagen Cross-linking in patients with keratoconus
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
- contact lens intolerance
- corneal thickness > 450 micrometers
- Keratometry < 56 diopters
- Astigmatism < 6 diopters
Exclusion Criteria
- corneal thickness < 450 micrometers
- Keratometry > 56 diopters
- Astigmatism > 6 diopters
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The change of visual acuity following Photorefractive Keratectomy and Corneal Collagen Cross-linking in patients with Keratoconus 6 months The change of visual acuity from baseline in patients suffering from keratoconus following treatment with Photorefractive Keratectomy and Corneal Collagen Cross-linking.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the efficacy of corneal cross-linking in keratoconus treatment?
How does combined photorefractive keratectomy and cross-linking compare to sequential treatment approaches in keratoconus?
Which corneal biomarkers predict optimal outcomes for simultaneous PRK and CXL in keratoconus patients?
What are the long-term adverse event profiles of surface ablation plus cross-linking in progressive keratoconus?
Are there alternative collagen-modifying agents or combination therapies for keratoconus treatment development?