Surface Ablation With Corneal Cross Linking in Mild Keratoconus

Not Applicable

• Conditions: Keratoconus; Corneal Cross-Linking
• Interventions: Procedure: Photorefractive Keratectomy with Corneal Cross-Linking

• Registration Number: NCT05176171
• Lead Sponsor: Shahid Beheshti University

Brief Summary

Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups. The four groups underwent topography- and non-topography-guided PRK with sequential and simultaneous CXL. The main outcome measures will be pre-and postoperative uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (CDVA), manifest refraction, contrast sensitivity, and keratometry

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-05
• Primary Completion: 2019-03-05
• Study First Submitted: 2020-04-05
• Status Verified: 2022-01
• Study First Submitted QC: 2022-01-03
• Study First Posted: 2022-01-04
• Last Update Submitted: 2022-04-10
• Last Update Posted: 2022-04-18
• Study Completion: 2023-07-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Photorefractive Keratectomy with Corneal Cross-Linking	Photorefractive Keratectomy with Corneal Cross-Linking	For correction of refractive error

Primary Outcome Measures

Name	Time	Method
Visual Acuity	3 year	Evaluation of the uncorrected visual acuity, best corrected visual acuity, astigmatism, intraocular pressure and endothelial cell loss before and after the last operation.

Trial Locations

Locations (1)

Negah Eye Hospital; 🇮🇷 Tehran, Iran, Islamic Republic of