The Postoperative Analgesic Effect of Dexamethasone Added to Topical Bupivacaine in Endoscopic Nasal Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Analgesic consumption
研究概览
简要总结
Nasal packing is frequently applied after nasal surgery. Nasal packing reduces epistaxis, prevents septal hematoma and stabilizes nasal septum. Nasal mucosa is quite sensitive to pain, therefore the most common problems after surgery are postoperative pain and anxiety during removal of the nasal packing. Lots of methods have been tried to control this pain (non-steroidal anti-inflammatory drugs, nerve blockade with long-acting local anesthetics, local anesthetics infiltration into nasal packing).
Glucocorticoids have been used as an adjuvant in the management of acute postoperative pain. Perineural dexamethasone as an adjuvant for the single-injection nerve block can prolong analgesia and reduce opioid-requiring after surgery. Furthermore dexamethasone reduces postoperative nausea and vomiting incidance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologist's physiologic state I-II patients undergoing nasal surgery
排除标准
- •chronic pain
- •bleeding disorders
- •renal or hepatic insufficiency
- •patients on chronic non-steroidal anti-inflammatory medications
- •emergency cases
研究组 & 干预措施
Group Bupivacaine
4 ml %0.5 bupivacaine and 1 ml %0.9 NaCl infiltration into nasal packing to both sides
干预措施: Bupivacaine (Drug)
Group Bupivacaine+Dexamethasone
4 ml %0.5 bupivacaine and 4mg(1 ml) dexamethasone infiltration into nasal packing to both sides
干预措施: Bupivacaine (Drug)
Group Bupivacaine+Dexamethasone
4 ml %0.5 bupivacaine and 4mg(1 ml) dexamethasone infiltration into nasal packing to both sides
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Analgesic consumption
时间窗: Postoperative 24 hours
Analgesic consumption first 24 hours
次要结局
- Visual analog pain score(postoperative 24th hour)