Effects of Milk Powder Intervention on Body Composition and Physical Performance in Middle-aged and Older Adults
- Conditions
- Healthy
- Registration Number
- NCT06429410
- Lead Sponsor
- Huilian Zhu
- Brief Summary
This study aims to conduct a 24-week intervention involving formula milk powder for middle-aged and elderly individuals, assessing its impact on body composition and physical performance in comparison to interventions using regular milk powder and individuals without intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Aged 50 years old and older;
- BMI <22kg/m2;
- Calf circumference <33cm in women or <34cm in men, or SARC-F ≥ 4, or SARC-Claf ≥ 11;
- Living in Guangzhou and having no plan to move in the next 6 months;
- Willing to participate in the study.
- Lactose intolerance;
- Complicated with severe diseases;
- Unable to conduct study procedures;
- Participating in any other intervention studies.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method lean body mass up to 24 weeks At baseline, and 24 weeks, investigators will use DXA to examine lean body mass and fat composition.
- Secondary Outcome Measures
Name Time Method muscle strength up to 24 weeks At baseline, 12, and 24 weeks, investigators will test hand grip to assess muscle strength.
physical performance up to 24 weeks At baseline, 12, and 24 weeks, investigators will test the Short Physical Performance Battery (SPPB) to assess muscular function.
the levels of blood metabolic markers for bone and muscle up to 24 weeks At baseline, and 24 weeks, blood samples will be drawn and serum indexes of bone and muscle metabolism will be test, including myostatin, PINP, CTx, and osteocalcin.
cardiorespiratory fitness up to 24 weeks At baseline, and 24 weeks, investigators will use cardiopulmonary exercise testing (CPET) on a cycle ergometer to evaluate cardiorespiratory fitness.