Clinical Outcomes of Peroral Endoscopic Myotomy for Esophageal Outflow Obstruction
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- number of patients with Eckardt score <3 after the procedure
研究概览
简要总结
Esophageal outflow obstruction is characterized by failure to relax the lower esophageal sphincter (LES), resulting in impaired flow of ingested food into the stomach. The subsequent stasis of ingested food leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss. The core objective of the treatment of esophageal outflow obstruction is to disrupt the LES and reduce its pressure to allow esophageal emptying. Therapeutic options include pharmacologic therapy, Botulinum toxin injection, pneumatic balloon dilation, and surgical myotomy with partial fundoplication. In addition, peroral endoscopy myotomy (POEM) has recently been introduced as a minimally invasive treatment, but there have a few studies regarding long-term outcomes. The aim of this study is to evaluate clinical outcomes of POEM for esophageal outflow obstruction.
详细描述
Prospective study
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were diagnosed as esophageal outflow obstruction
- •Patients with informed consent
排除标准
- •Diagnostic uncertainty
- •Patients who are not suitable for general anesthesia
结局指标
主要结局
number of patients with Eckardt score <3 after the procedure
时间窗: 1 month after the procedure
次要结局
- adverse events which are related to the procedure(within 30 days)
研究者
Hwoon-Yong Jung
Professor
Asan Medical Center