Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions

Not Applicable

Not yet recruiting

• Conditions: Gingival Recession

• Registration Number: NCT06986525
• Lead Sponsor: Pamukkale University

Brief Summary

This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.

Detailed Description

The objective of this prospective clinical trial is to compare two mucogingival surgical techniques-coronally advanced flap (CAF) and tunnel technique-used in combination with platelet-rich fibrin (PRF) for treating multiple Miller Class I-II gingival recessions. Eleven systemically healthy participants with bilateral gingival recessions will be enrolled. CAF+PRF will be applied on one side, and Tunnel+PRF on the contralateral side. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level, recession height and width, and keratinized tissue height will be recorded at baseline, 3 months, and 6 months. Root coverage outcomes and clinical attachment gain will be analyzed.

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-05-09
• Study Start: 2025-05-15
• Study First Submitted QC: 2025-05-22
• Last Update Submitted: 2025-05-22
• Study First Posted: 2025-05-23
• Last Update Posted: 2025-05-23
• Primary Completion: 2025-12-15
• Study Completion: 2025-12-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Age 18 years or older
• Systemically healthy individuals
• Presence of bilateral Miller Class I-II multiple gingival recessions
• Good oral hygiene and willingness to follow instructions
• Signed informed consent

Exclusion Criteria

• Use of tobacco or smoking
• Pregnancy or lactation
• Presence of systemic diseases affecting periodontal health
• Use of medications that may affect healing (e.g., corticosteroids)
• Periodontal surgery in the same area within the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in Recession Height (RH)	Baseline and 6 Months	Recession height will be measured in millimeters from the cementoenamel junction to the gingival margin using a periodontal probe at baseline and 6 months postoperatively.

Secondary Outcome Measures

Name	Time	Method
Change in Clinical Attachment Level (CAL)	Baseline, 3 Months, and 6 Months	Clinical attachment level will be measured in millimeters using a periodontal probe to assess periodontal healing at different time points.

Trial Locations

Locations (1)

Pamukkale University, Faculty of Dentistry, Periodontology; 🇹🇷 Denizli, Turkey