Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 152
- 主要终点
- variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest
研究概览
简要总结
Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.
Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients under 65 years
- •Schizophrenics, bipolar or schizoaffective (DSM IV)
- •Patients who signed informed consent
排除标准
- •Women with childbearing potential without effective contraception or positive pregnancy test.
- •Contra-indications to fMRI
研究组 & 干预措施
Neuropsychiatric Disorders
Neuropsychiatric Disorders patients
干预措施: language task and a reference task (rest and Tamil) (Other)
Neuropsychiatric Disorders
Neuropsychiatric Disorders patients
干预措施: IMRf (Device)
Healthy volunteers
control subjects matched to patients by age, sex, socio-cultural level and laterality
干预措施: IMRf (Device)
Healthy volunteers
control subjects matched to patients by age, sex, socio-cultural level and laterality
干预措施: language task and a reference task (rest and Tamil) (Other)
结局指标
主要结局
variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest
时间窗: baseline
次要结局
未报告次要终点