Language Function in Patients With Brain Tumors

Completed

• Conditions: Brain Cancer; CNS Cancer
• Interventions: Other: fMRI Scan, pre- and post language evaluation

• Registration Number: NCT00599703
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-05
• Study First Submitted: 2008-01-11
• Study First Submitted QC: 2008-01-11
• Study First Posted: 2008-01-24
• Primary Completion: 2009-03
• Study Completion: 2009-03
• Status Verified: 2009-07
• Last Update Submitted: 2009-07-07
• Last Update Posted: 2009-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.
• At least 18 years of age
• English as first language

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Exclusion Criteria

• Patients with high grade tumors
• History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia),
• History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease.
• History of significant claustrophobic reactions.
• Pregnancy
• Standard contraindications to MR examinations (e.g. implanted stimulator)
• Patients, who were treated prior to our first scan, will not be eligible to participate in this study

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	fMRI Scan, pre- and post language evaluation	neurosurgical patients

Primary Outcome Measures

Name	Time	Method
To identify language organization prior to surgery in patients in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.	conclusion of study

Secondary Outcome Measures

Name	Time	Method
To assess language reorganization over time.	conclusion of study

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States