Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects
Not Applicable
Completed
- Conditions
- Neuropsychiatric Disorders
- Registration Number
- NCT02523742
- Lead Sponsor
- University Hospital, Caen
- Brief Summary
Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.
Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 152
Inclusion Criteria
- patients under 65 years
- Schizophrenics, bipolar or schizoaffective (DSM IV)
- Patients who signed informed consent
Exclusion Criteria
- Women with childbearing potential without effective contraception or positive pregnancy test.
- Contra-indications to fMRI
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest baseline
- Secondary Outcome Measures
Name Time Method