Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects

Not Applicable

Completed

• Conditions: Neuropsychiatric Disorders
• Interventions: Device: IMRf; Other: language task and a reference task (rest and Tamil)

• Registration Number: NCT02523742
• Lead Sponsor: University Hospital, Caen

Brief Summary

Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.

Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-11
• Primary Completion: 2013-11-19
• Study Completion: 2015-04-23
• Status Verified: 2015-08
• Study First Submitted: 2015-08-13
• Study First Submitted QC: 2015-08-13
• Study First Posted: 2015-08-14
• Last Update Submitted: 2020-08-31
• Last Update Posted: 2020-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

• patients under 65 years
• Schizophrenics, bipolar or schizoaffective (DSM IV)
• Patients who signed informed consent

Exclusion Criteria

• Women with childbearing potential without effective contraception or positive pregnancy test.
• Contra-indications to fMRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Neuropsychiatric Disorders	IMRf	Neuropsychiatric Disorders patients
Healthy volunteers	IMRf	control subjects matched to patients by age, sex, socio-cultural level and laterality
Neuropsychiatric Disorders	language task and a reference task (rest and Tamil)	Neuropsychiatric Disorders patients
Healthy volunteers	language task and a reference task (rest and Tamil)	control subjects matched to patients by age, sex, socio-cultural level and laterality

Primary Outcome Measures

Name	Time	Method
variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest	baseline