Dexamethasone Dosing Interval: 12 or 24 Hours Apart? A Randomized,Clinical Trial
概览
- 阶段
- 2 期
- 干预措施
- Dexamethasone 12
- 疾病 / 适应症
- Prematurity
- 发起方
- Assiut University
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- respiratory distress syndrome (RDS)
- 状态
- 已完成
- 最后更新
- 13年前
概览
简要总结
The investigators sought to determine whether the incidence of neonatal respiratory distress syndrome (RDS) in preterm fetuses is similar with 12- vs 24-hour dosing interval of dexamethasone.
详细描述
The administration of glucocorticoids to accelerate fetal lung maturity in patients with preterm delivery plays an important role for obstetrics and neonatal care. Many studies have shown that maternal administration of glucocorticoids has a significant beneficial effect in decreasing the incidence of respiratory distress syndrome (RDS) in infants delivered at 28-34 weeks of gestation.
研究者
Mohammed Khairy Ali
Women Health Hospital
Assiut University
入排标准
入选标准
- •All patient with threatened or established preterm labor between 28 - 34 weeks attended to our emergency unit
排除标准
- •emergent obstetric conditions like:
- •Antepartum hemorrhage in severe attack
- •Antepartum eclampsia
研究组 & 干预措施
12 hours Dexamethasone
Those patient will be given 12 hours dexamethasone after randomization
干预措施: Dexamethasone 12
24 hours Dexamethasone
Those patient will be give 24 hours dexamethasone after randomization
干预措施: Dexamethasone 24 hours
结局指标
主要结局
respiratory distress syndrome (RDS)
时间窗: 6 month
determine whether the incidence of neonatal respiratory distress syndrome (RDS) is similar with 12- vs 24-hour dosing interval of dexamethasone.
次要结局
- Perinatal mortality(6 month)