Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Special care baby unit
研究概览
简要总结
Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally. In developing countries resources are scarce and it is difficult to provide expensive treatments as neonatal care.
Aim of the Work: To assess the effect of prophylactic dexamethasone administration before elective cesarean section at term in reducing neonatal respiratory complications.
Patients and methods: 600 women were included in the study and were planned to have elective caesarean section. 300 received dexamethasone 12 mg twice, 12 hours apart 48 hours before delivery. 300 patients were the control group.
The outcomes were: incidence of admission to neonatal intensive care unit (NICU), incidence of transient tachypnea of newborn (TTN), the incidence of respiratory distress syndrome (RDS) and the need for mechanical ventilation.
详细描述
Dexamethasone which is a long acting corticosteroid can be used prior to elective cesarean section to decrease neonatal respiratory morbidity by enhacing fetal lung maturity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 22 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Previous caesarean section
- •Complete 37 week calculated from the first day of the last menstrual period.
排除标准
- •Obstetric complications such as pre-eclampsia, antepartum hemorrhage or known fetal anomaly.
- •Hypertensive patients.
- •Chronic disease e.g. diabetes mellitus.
- •Known renal disease.
- •Pre-operative infection.
研究组 & 干预措施
Dexamethasone
Dexamethasone, im , 12 mg twice, 12 hrs apart, 48 hrs before elective cesarean section
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Special care baby unit
时间窗: 24 hours
Special care baby unit admission for babies with respiratory distress
次要结局
- Severity of respiratory distress(24 hours)
研究者
Noha Rabei
Assistant Professor, Obstetrics and Gynecology
Ain Shams Maternity Hospital