Comparative clinical study to evaluate two different modalities of Shodhananga snehapana with Murchita tila taila and Varunadi ghrita followed by Virechana in dyslipidaemia
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Studies have shown normalcy of the lipid profile
研究概览
简要总结
Studies have been conducted to manage dyslipidaemia through Panchakarma procedures involving Snehapana and Virechanakarma. Lipid profile regulation noted in the studies. The studies involved gradual increase of snehapana dose as per the agni. In Vangasena Samhita we get reference of fixed increase of snehapana dose not involving agni assessment. The present study is planned to compare these two modes of snehapana with Murchita tila taila and Varunadi ghrita followed by Virechana in dyslipidaemia
OBJECTIVES OF THE STUDY
1.Primary objective
a.To assess the effect of Arohana krama of Snehapana with Murchita tila taila followed by Virechana in dyslipidaemia
b.To assess the effect of fixed dose of Arohana krama Snehapana with Murchita tila taila followed by Virechana in dyslipidaemia
c.To assess the effect of Arohana krama of Snehapana with Varunadi ghrita followed by Virechana in dyslipidaemia
d.To assess the effect of fixed dose of Arohana krama Snehapana with Varunadi ghrita followed by Virechana in dyslipidaemia
2.Secondary objective
a.To assess the Samyak snigdha lakshanas
b.To assess the Samyak Virikta Lakshanas
c.To study the changes in biochemical parameters
d.To compare between the groups
Study design
CONTROLLED COMPARATIVE CLINICAL TRIAL
Study type : Interventional
Estimated enrolment : Minimum of 100 participants
Allocation : Randomized
Interventional Model : Two Arm Parallel Assignment
Masking : Open Label Study
Primary purpose : Treatment
Drugs
*For Deepana Pachana with Ajamodadi churna
*For Udwartna with Kolakulatthadi churna
*Snehana with Murchita tila taila and Varunadi ghrita
*Virechana with Vidanga Tanduladi yoga
*Samsarjana krama
Subjective parameters
Before and after Deepana pachana
Agni
Ama
Kostha
For Samyak snigdha lakshanas
Vatanulomana
Agnidipti
Snehodvega
Klama/Glani
Angalaghavata
Purisha- Twak- Gatra snigdhata
Sneha -jeerya maana lakshanas
For Virechana
Laingiki Shuddhi
Antiki Shuddhi
Objective parameters
Weight
BMI
Chest circumference
Mid-arm circumference
Waist circumference
Mid-thigh circumference
Resting metabolism
Body fat percentage
Visceral fat level
For Dyslipidaemia
Total Cholesterol
Triglycerides
LDL
HDL
For Virechana
Vegiki Shuddhi
Investigation: Lipid profile & CRP
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •BMI Range from 18.5 to 34.9 will be taken for the study • Subjects with borderline high and high as per the NCEP ATP III criteria • Subjects fit for Virechana • Subjects between 30 to 60yrs of age.
排除标准
- •Having associated disorders like Diabetes Hypothyroidism Nephrotic syndrome Obstructive liver disease Chronic renal failure Drugs, that may raise LDL cholesterol or cause another dyslipidaemia.
结局指标
主要结局
Studies have shown normalcy of the lipid profile
时间窗: Baseline, Day 11, Day 16 and Day24
次要结局
- Lipid profile may come normal(Before and after the study)
研究者
DrSuma S Sadar Joshi
SDM College of Ayurveda and Hospital, Hassan