Development and validation of a clinical prediction model for psychotic relapse within 12 months after discharge in people with schizophrenia
- Conditions
- Schizophrenia and related disorders
- Registration Number
- JPRN-UMIN000043345
- Lead Sponsor
- Department of Health Promotion and Human Behavior, Kyoto University School of Medicine
- Brief Summary
The significant predictors were the number of previous hospitalizations (HR 1.42, 95% CI 1.22-1.64) and the current length of stay in days (HR 1.31, 95% CI 1.04-1.64). In model development for relapse, Harrells c-index was 0.59 (95% CI 0.55-0.63). The internal and internal-external validation for rehospitalization showed Harrells c-index to be 0.64 (95% CI 0.59-0.69) and 0.66 (95% CI 0.57-0.74), respectively. The calibration plot was found to be adequate
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 805
Not provided
Patients with the following conditions will be excluded: - Those who had been enrolled in this study with a previous episode of hospitalisation due to psychosis (i.e. a patient cannot be enrolled more than once during the study period) - Those with substance/medication-induced psychosis - Those with psychosis due to another medical condition, including peri-and postpartum psychosis and psychosis in dementia - Those with diagnosis in the inclusion criteria whose admission are not due to psychosis as judged by one of investigators - Those with diagnosis in the inclusion criteria with which one of investigators disagree due to the lack of sound reasoning - Those discharged from a non-acute ward - Those with a plan to be readmitted in the short period of time - Those with ambiguous diagnosis as judged by one of investigators - Those discharged to another psychiatric hospital - Those discharged to medical hospital
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Psychotic relapse as a composite outcome defined by an occurrence of any one of the following: psychiatric hospitalisation, psychiatrist's decision that hospitalisation is required, an increase in antipsychotic dosage, an increase in the level of psychiatric care, and violence to self and/or others. Participants will be followed up up to 12 months after their discharge from the index hospitalisation.
- Secondary Outcome Measures
Name Time Method Psychiatric hospitalisation due to psychotic relapse