The role of sleep in emotional memory processing and neurocognitive functioning in patients with posttraumatic stress disorder

Completed

Conditions: posttraumatic stress syndrome
10002861
Posttraumatic stress disorder

Registration Number: NL-OMON37626

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

Inclusion criteria for the PTSD group are:
1) Meeting diagnostic criteria for PTSD according to Clinician-Administered PTSD Scale (CAPS) with a total score of at least 50;
2) Age between 18 and 65;
3) Eligible for trauma-focused psychotherapy;
4) Written informed consent.;Inclusion criteria for the trauma-exposed control group are:
1) Having experienced at least one traumatic event as defined by DSM-IV in the absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview;
2) Age between 18 and 65;
3) Written informed consent.;Inclusion criteria for the non-trauma exposed control group are:
1) Having experienced no traumatic events as defined by DSM-IV and absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview;
2) Age between 18 and 65;
3) Written informed consent.

Exclusion Criteria

Exclusion criteria for all groups are:
1) Acute suicidality;
2) Presence of a psychotic disorder, bipolar disorder, depression with psychotic features, or excessive substance related disorder over the past 3 months;
3) Prior history of neurological or sleep disorders, or an atypical sleep pattern with less than 6 hours sleep per night, or sleep time outside the window of 10 PM till 10 AM (for the PTSD group: neurological or sleep disorders prior to onset of PTSD).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameters are memory for emotional and neutral film<br /><br>fragments, physiological signals during film fragments (ECG, respiratory<br /><br>effort, galvanic skin response), and emotional responses during the film<br /><br>fragments. Further main study parameters are neurocognitive functions<br /><br>(attention, planning, declarative memory). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlates of sleep architecture will also be investigated in stress hormones.<br /><br>For the patient group, predictive effects of sleep architecture and memory<br /><br>processes on response to treatment will be studied.</p><br>