Sleeping behavior and Memory consolidation in patients with severe disorders of consciousness. Substudy 1: Sleep screening of patients in persistent vegetative state

• Conditions: G93.80; G82; G61.0; Paraplegia and tetraplegia; Guillain-Barré syndrome

• Registration Number: DRKS00009326
• Lead Sponsor: Eberhard Karls Universität TübingenInstitut für Medizinische Psychologieund Verhaltensneurobiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02-15
• Study Completion: 2018-02-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patientgroup 1:
-Non-traumatic or traumatic brain damage (e.g. hypoxia, ischemic and hemorrhagic cerebral infarction)
-VS or MCS diagnose (classification according to CRSr, Coma Recovery Scale – revised).
stratification: 20 MCS patients, 20 VS patients -injury occurred between 4 weeks and 12 month ago
-stabile vital functions (blood pressure, pulse, temperature)

Patientgroup 2:
- Patient, who is confined to his/her bed with the diagnose Paraparese, Paraplegie, Tetraparese, Tetraplegie (G82) or Gullain-Barré-Syndrom (G61.0)
-stabile vital functions (blood pressure, pulse, temperature)

Exclusion Criteria

-Severe slowdown of EEG-Basicactivity (1 - 3 Hz)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
For each patient a one-time 24 hour recording of sleeping behavior is conducted. The EEG-channels F3, Fz, F4, C3, Cz, C4, P3, Pz, P4 the electrooculogramm (EOG1, EOG2) and the electromyogramm (EMG1, EMG2, EMG3) are recorded. In addition two referential electrodes are attached and a video recording for data evaluation is made. Before sleep recording a short EEG-measurement, during which in the form of an oddball-paradigm participants are stimulated on a auditive and tactile level is conducted. Via the evaluation of the EEG-/ EOG- and EMG-recordings (according to Rechtschafen & Kales, 1968 and Valente et al., 2002) an estimation of sleep is planed. In epochs with electromagnetic interference the video recordings should give clarity on the underlying events.

Secondary Outcome Measures

Name	Time	Method
There are no secondary endpoints required.