Does Mycobacterium ulcerans colonise skin prior to clinical Buruli ulcer?

Not Applicable

Completed

• Conditions: Mycobacterium ulcerans; Buruli Ulcer; Infection - Studies of infection and infectious agents; Skin - Other skin conditions

• Registration Number: ACTRN12619000998145
• Lead Sponsor: Austin Health

Brief Summary

We found no evidence that adult humans with outdoor exposure in Buruli endemic areas have skin contamination with M. ulcerans.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-04-30
• Study Start: 2019-07-15
• Last Update Posted: 10 April 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

BU patients known to the principal investigator or the Infectious Diseases team at Austin Health who spend time in an endemic area. Friends and relatives of these patients recruited through the index patient, who stay with or spend time with them in the endemic area. Scientists working with our research team who spend a whole day in the endemic area collecting samples will also be recruited.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of participants with detected M. ulcerans on their skin detected by PCR.[Swabs will be collected at a single time point on one day chosen by the participant on a day when he or she has been outside for several hours and tested as soon as possible after arrival at our research laboratory, planned to be within 2 weeks.]

Secondary Outcome Measures

Name	Time	Method
Open question in a questionnaire designed specifically for this study to describe activities on the day of swab collection. Participants are free to elaborate as much as they like.[Same day as swab collection.];Open question in a questionnaire designed specifically for this study to describe the amount of clothing at the time of swab collection. Divided in covered or bare upper/lower limbs and feet. Participants could further specify for if they changed for different activities or if they wore protective clothing. [Same day as swab collection.]