Conservative versus liberal oxygenation targets in patients undergoing one-lung ventilation during thoracic surgery for lung resection: A Pilot single-center randomized controlled trial
Not Applicable
- Conditions
- ung cancer
- Registration Number
- JPRN-UMIN000039461
- Lead Sponsor
- Okayama University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
Not provided
Exclusion Criteria
1. Bilateral lung resection 2. Receiving surgery with one-lung ventilation during the past one month 3. Estimated surgery time <2 hours 4. ASA physical status =>4 5. Known chronic obstructive pulmonary disease 6. Urgent or time-critical surgery 7. Severe anemia (hemoglobin <8 g/dL) 8. Judged inappropriate for participation by the researchers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Radiological atelectasis score of the dependent lung just after surgery
- Secondary Outcome Measures
Name Time Method *Radiological atelectasis score of the dependent lung on postoperative day (POD)1 *PaO2/FIO2 ratio just after surgery and on POD1 *Time-weighted average of SpO2 and FIO2 during surgery *Sequential Organ Failure Assessment (SOFA) score on POD1 and POD2 *Postoperative complications within 7 days following surgery (Clavien-Dindo classification grade =>III) *AKI within 2 days following surgery (defined using KDIGO creatinine criteria) *Hospital-free days at 28 days *Hypoxemia during surgery (SpO2 <88% continues for more than 2min) *Severe hypoxemia during surgery (SpO2 =<85% continues for more than 2min)