Perfusion index derived from a pulse oximeter to predict fluid responsiveness in patients with acute circulatory failure in the intensive care unit

Not Applicable

• Conditions: Patients with acute circulatory failure; Circulatory System

• Registration Number: ISRCTN53719438
• Lead Sponsor: Hospital Angeles Tijuana

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-20
• Last Update Posted: 7 June 2021
• Study Completion: 2021-10-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

1. Age greater than or equal to 18 years
2. With spontaneous ventilation
3. Patients with acute circulatory failure, defined as:
3.1. Hypotension (systolic blood pressure <90 mmHg and/or mean arterial pressure <65 mmHg, or drop in mean arterial pressure =40 mmHg from baseline), and/or
3.2. Use of vasopressors, associated with:
3.3. Signs of hypoperfusion (altered mental state, oligoanuria, lactate greater than or equal to 2 mmol/L, clinical skin changes associated with hypoperfusion)

Exclusion Criteria

1. Presence of atrial fibrillation
2. Invasive mechanical ventilation in controlled modalities
3. Situations in which a passive leg raising maneuver is contraindicated (head trauma, deep vein thrombosis in the pelvic limbs, intra-abdominal hypertension> 12 mmHg)
4. Patients with a poor echocardiographic window and in whom an adequate 5-chamber apical window cannot be obtained
5. Patients whose echocardiogram shows aortic stenosis and insufficiency

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Perfusion index and velocity integral time will be measure at baseline (time 0), after a passive leg-raising maneuver (time 1), and semi-fowler position after 2 minutes (time 2).<br> (The changes of the (perfusion index) PI and (velocity integral time) VTI will be represented in relative changes:<br> [PI before the maneuver (time 0) - PI after the maneuver (time 1)] / PI before the maneuver (time 0) x 100<br> and, [VTI before the maneuver (time 0) - VTI after the maneuver (time 1)] / IVT before the maneuver (time 0) x 100 respectively. A passive leg-raising maneuver will be defined as positive when an increase in VTI greater than or equal to 15%.)<br>

Secondary Outcome Measures

Name	Time	Method
There are no secondary outcome measures