Functional Evaluation of Distal Airways by Forced Oscillations: Diagnosis Help in Bronchiolitis Obliterans Syndrome in Post Bone Marrow Transplantation

Hopital Foch2 sites in 1 country110 target enrollmentJune 2011

ConditionsBronchiolitis Obliterans Bone Marrow Transplantation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Bronchiolitis Obliterans
Sponsor: Hopital Foch
Enrollment: 110
Locations: 2
Primary Endpoint: Number of days
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

A study to evaluate the role of forced oscillations in diagnosis of bronchiolitis obliterans syndrome in patients after bone marrow transplantation. The force oscillations technique will be compared with classical spirometry.

Registry

clinicaltrials.gov

Start Date

June 2011

End Date

September 2015

Last Updated

7 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Hopital Foch

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients over 18 years
•Bone marrow or hematopoietic stem cells transplantation for more than 100 days
•Clinical stability
•Patients affiliated to a social security system
•Patients having given his (her) written consent.

Exclusion Criteria

•Bronchiolitis Obliterans already diagnosed
•Unresolved Respiratory infection
•Unresolved mechanical complication (pneumothorax, effusions)
•Medicinal pneumopathy
•Inability to perform pulmonary function tests

Outcomes

Primary Outcomes

Number of days

Time Frame: 2 years

Temporal difference between the date of the functional change measured by the technique of the forced oscillations and by the standard techniques of plethysmography.