Obsessive Compulsive Treatment Efficacy Trial (OCTET)

Not Applicable

Completed

• Conditions: Obsessive compulsive disorder; Mental and Behavioural Disorders

• Registration Number: ISRCTN73535163
• Lead Sponsor: niversity of Manchester (UK)

Brief Summary

2014 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/25011730 protocol 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28654682 results 2017 Results article in https://pubmed.ncbi.nlm.nih.gov/28681717/ Clinical effectiveness, cost-effectiveness and acceptability (added 24/01/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-04-05
• Study Completion: 2015-08-31
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 475

Inclusion Criteria

Current inclusion criteria as of 17/09/2014:
1. Adults aged 18 and above meeting Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria for obsessive compulsive disorder (assessed using six OCD questions from the Mini-International Neuropsychiatric Interview [M.I.N.I.])
2. Scoring 16 or over on the Yale Brown Obsessive Compulsive Checklist (YBOCS)
3. On a waiting list for therapist-led cognitive behavioral therapy (CBT) in either primary or secondary mental health care settings
4. Able to read English at a level of 11 years and above

Previous inclusion criteria:
1. Adults aged 18 and above meeting Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria for obsessive compulsive disorder (assessed using the Structured Clinical Interview for DSM-IV [SCID-IV])
2. Scoring 16 or over on the Yale Brown Obsessive Compulsive Checklist (YBOCS)
3. On a waiting list for therapist-led cognitive behavioral therapy (CBT) in either primary or secondary mental health care settings
4. Able to read English at a level of 11 years and above

Exclusion Criteria

Current exclusion criteria as of 17/09/2014:
1. Participants who are actively suicidal
2. Patients with organic brain disease
3. Those who are experiencing psychosis
4. Those who have a diagnosis (DSM IV) criteria of drug or alcohol misuse
5. Patients who are currently receiving a psychological treatment for OCD
6. Those who have literacy or language difficulties to an extent which would preclude them from reading written or web-based materials or conversing with a health professional

Previous exclusion criteria:
1. Participants who are actively suicidal
2. Patients with organic brain disease
3. Those who are experiencing psychosis
4. Those who have a diagnosis (DSM IV) criteria of drug or alcohol misuse
5. Patients who are currently receiving a psychological treatment for OCD
6. Patients who have received CBT for OCD in the last 6 months
7. Those who have literacy or language difficulties to an extent which would preclude them from reading written or web-based materials or conversing with a health professional
8. Patients who have been prescribed or changed to an alternative anti-depressant in the 12 weeks prior to assessment will be excluded. These patients will be offered a further assessment following 12 weeks of stable medication if there are no plans to increase the medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Yale-Brown Obsessive Compulsive Scale (Y BOCS) checklist

Secondary Outcome Measures

Name	Time	Method
<br> 1. Self-reported health-related quality of life (SF-36)<br> 2. Self-reported OCD symptoms (YBOCs self-rated)<br> 3. Generic mental health (CORE-OM)<br> 4. Depression (PHQ9)<br> 5. Anxiety (GAD-7)<br> 6. Functioning (WSA)<br> 7. Health-related quality of life (EQ5D)<br> 8. Employment status (IAPT Employment Status questions A13 ?A15)<br> 9. Patient satisfaction (CSQ) and acceptability (qualitative interviews)<br> 10. Percentage of patients not improved or partially improved requiring more intensive CBT<br><br> Added 17/09/2014:<br> 11. Adult Service Use Schedule (AD-SUS) ? self complete and interview<br>