Comparison of Bupivacaine plus magnesium sulphate with Ropivacaine plus magnesium sulphate local infiltration of wound for most op analgesia

Not yet recruiting

• Conditions: Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere,

• Registration Number: CTRI/2019/04/018833
• Lead Sponsor: Dr Anuja Agrawal

Brief Summary

Management of acute post-operative pain has received keen attention in recent years with considerable concurrent advancement in the field. Major abdominal surgeries with upper abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery. The choice of post-operative analgesic modality employed after major abdominal surgeries at our university hospital is at the discretion of the primary anesthesiologist responsible for managing the patient in the operating room. The choice mainly depends upon the strategy favored by the concerned anesthesiologist and the availability of drugs and equipment. The supply of drugs is erratic and the quantity of equipment might not be sufficient for every patient. With these objectives in mind and in this era of opioid free analgesia, we designed this prospective observational study to evaluate postoperative pain in patients undergoing upper abdominal surgery with local anaesthetics bupivacaine and ropivacaine with NMDA adjuvant; magnesium sulphate.

So far, there are no clinical studies comparing the efficacy of magnesium sulfate when combined with local anesthetic agents, such as bupivacaine and ropivacaine for upper abdominal surgical site infiltration. The objective of this study is to assess and compare the effectiveness and safety of local infiltration of bupivacaine combined with magnesium sulfate and ropivacaine combined with magnesium sulfate for postoperative analgesia in patients undergoing upper abdominal surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-30
• Last Update Posted: 2021-02-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Age >18 years <60 years ASA-I, II and III Patient willing to sign informed consent.
• Mallampatti class I and II Upper abdominal surgeries eg.
• Open Cholecystectomy, Laprotomies, upper abdominal wall mass, etc.

Exclusion Criteria

• Patient’s refusal.
• ASA IV Mallampatti class III and IV Known allergy of any of the drugs Patient not planned for extubation after the surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of Analgesia	24 hrs

Secondary Outcome Measures

Name	Time	Method
VAS At different time intervals	0,2,4,6,8,10,12,14,16,18,20,22,24

Trial Locations

Locations (1)

Dhiraj Hospital; 🇮🇳 Vadodara, GUJARAT, India

Dhiraj Hospital

🇮🇳Vadodara, GUJARAT, India

Dr Anuja Agrawal

Principal investigator

9687798989

anujagyl@gmail.com