Clot removal plus decompressive craniectomy in surgical treatment of patients with hypertensive intracranial hemorrhage

Not Applicable

• Conditions: hypertensive intracranial hemorrhage; Neurological - Other neurological disorders; Stroke - Haemorrhagic; Cardiovascular - Hypertension

• Registration Number: ACTRN12613000459729
• Lead Sponsor: Ke Wang

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

(1)patients who suffered from hypertensive basal ganglia or putaminal hemorrhage with a least volume of 30 mL; (2) admitted within 24 hours after ictus; (3) the Glasgow Coma Scale score of 4 or higher; (4) informed consent is obtained from family members

Exclusion Criteria

(1) Failure to obtain informed consent; (2) Presence of coagulation disorders or thrombocytopenia before surgery; (3) Presence of chronic heart failure, respiratory insufficiency, liver dysfunction or renal impairment before surgery; (4) Patients on oral anticoagulant agents before admission.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
30-day mortality rate after stroke[Till death or 30 days after stroke];Functional outcome measured by the Glasgow Outcome Scale and modified Rankin Scale at 1-year follow-up.[Till death or one year after stroke]

Secondary Outcome Measures

Name	Time	Method
Postoperative intracranial pressure levels measured by itraoperativvely-implanted probes[Till death or seven days after the surgery];Manitol dosages after surgery[Till death or the first discharge];Complications during hospitalization including intracranial rebleeding confirmed by radiographic images, postoperative meningitis by cerebrospinal fluid culture and clinical symptoms, postoperative epilepsy by clinical symptoms, pneumonia by sputum culture and clinical symptoms, acute gastrointestinal bleeding, acute renal failure.[Till death or the discharge after cranioplasty];Duration of hospital stay[Till death or the dischrage after cranioplasty]