A clinical research to study the root resorption by estimating the levels of biomarker in the saliva and X- ray in patients undergoing fixed orthodontic therapy after injection of blood component(i-PRF) to fasten the orthodontic tooth movement.

Not yet recruiting

Brief Summary: Externalroot resorption is a common unfavorable side effect of orthodontic treatment.In orthodontic treatment approaches, the magnitude, duration, and type oforthodontic force application are important considerations. The maxillarylateral incisor had the highest root resorption, followed by the maxillarycentral incisor. The severity of rootresorption may be related to greater tooth mobility after orthodontictreatment. i-PRF is the second generation of platelet concentrates, and it hasthe advantage of gradually releasing growth factors over time. According tocurrent research, i-PRF accelerates tooth movement. There was no goldstandard for detecting and evaluating orthodontically caused root resorption(OIRR). Traditional radiography may not be sensitive enough to detectroot resorption in its early phases; however, evaluating root resorptionbiomarkers in GCF has been shown to be a safe and accurate alternative todiagnosing and monitoring OIRR.

Recruitment & Eligibility

Inclusion Criteria

patient with Class I / half cusp Class II malocclusion cases with moderate to severe crowding in maxillary arch (>6mm Littleâ€™s Irregularity Index).No previously reported or observed active orthodontic treatment.
Completed root apexification assessed with periapical radiographs.
Patients with healthy periodontium and no gingival inflammation at the experimental sites.
Patients with positive informed consent.

Exclusion Criteria

patient with Platelet count less than normal 150000 per Âµl of blood.
Patients on regular antibiotics, steroids or anti-inflammatory drugs.
Signs of external apical root shortening observed at the preoperative radiographic examination.
Non- compliant patient with poor oral hygiene.
Syndromic patients.

Primary Outcome Measures

Name	Time	Method
Estimate and compare levels of DSPP in GCF at different interval of time during alignment of maxillary incisors with and without i-PRF injection.	preoperative, before anterior alignment, 4 weeks, 8 weeks,3 month, 4 month, 6 month

Secondary Outcome Measures

Name	Time	Method
1.To estimate the amount and extent of root resorption in the maxillary incisors after alignment with and without i-PRF injection using CBCT.	preoperative and postoperative

Locations (1): AIIMS NEW DELHI
🇮🇳
South, DELHI, India
AIIMS NEW DELHI
🇮🇳South, DELHI, India
Dr JN Rupa
Principal investigator
8971770265
rupajn123@gmail.com