Binding interaction of polystyrene sulfonate and amitriptyline
- Conditions
- drug-drug interactionchronic renal failuredepressionneuropathic pain
- Registration Number
- NL-OMON26934
- Lead Sponsor
- Deventer Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 9
Inclusion Criteria
The participant is at least 18 years of age
Exclusion Criteria
-Known allergy to one of the investigated substances
-Known renal or hepatic impairment
-Pregnancy
-Breast feeding
-Use of other medication within 24 hours of the study period (oral contraceptives within 12 hours of the study period)
-Contra-indication for one of the investigated substances (such as recent myocardial infarction, cardiac arrhythmias, hypokalaemia and obstructive bowl disease)
-History of a gastro-intestinal condition that may interfere with absorption of amitriptyline
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine whether polystyrene sulfonate has an effect on exposure of amitriptyline, when taken simultaneously, compared to amitriptyline taken alone in healthy volunteers, expressed in Cmax and AUC0-8h.
- Secondary Outcome Measures
Name Time Method not applicable