MedPath

Longitudinal Study of Brain Amyloid imaGing in MEMENTO

Phase 3
Completed
Conditions
Alzheimer's Disease (AD) and Related Disorders
Interventions
Registration Number
NCT02164643
Lead Sponsor
University Hospital, Bordeaux
Brief Summary

A Multicenter national longitudinal cohort study including at least 800 individuals consecutively recruited from French Research Memory Centers and followed-up over 24 month and included in Memento.

Detailed Description

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting approximately 7.3 million people in Europe. AD is a clinicopathologic entity for which the definitive diagnosis requires both the presence of the clinical signs of dementia and pathological evidence of amyloid plaque in the brain (obtained at autopsy).

Currently, diagnosis of AD at early stage of the disease is hampered by the lack of noninvasive and validated biomarkers of the underlying pathology. On one hand, it is suggested that between 10% and 20% of patients currently diagnosed with AD, based on clinical evidence solely, lack AD pathology at autopsy, and on the other hand community physicians may not diagnose AD in 33% of patients with mild signs and symptoms. Thus, there is a need for validated diagnostic biomarker that could help clinicians separate patients who do not have AD from those who have pathological signs and should be referred for further evaluation and care management. Furthermore, little is known on the prognosis value for dementia conversion of current biomarkers of AD pathology at a preclinical or presymptomatic stage.

Recently, 18F-labeled positron emission tomography (PET) imaging agents have been developed that bind with high affinity to the amyloid-β (Aβ) peptide fibrils that constitute amyloid plaques, and thus, have potential value as an imaging biomarkers for amyloid deposits in subjects with cognitive impairment or isolated cognitive complaints.

The principal objective of this ancillary study is to investigate the prospective association between PET amyloid load, measured twice two years apart, through either Florbetapir (18F) or Flutemetamol (18F) radioligands, and dementia incidence over up to 5 years of follow-up in a sample of individuals presenting with a spectrum of cognitive profiles ranging from isolated cognitive complaints to cognitive deficits without dementia.

The secondary objectives are the following:

* To assess the association between change in amyloid load and clinical evolution of participants (both functional and cognitive)

* To estimate the prevalence of new research criteria for preclinical Alzheimer's disease

* To investigate long-term outcome of preclinical Alzheimer's disease according to NIA-AA criteria

* To assess the determinants of change in amyloid load over two years

* To study the interrelationships between biomarkers

* To assess the added value of amyloid binding agent (Florbetapir (18F) and Flutemetamol (18F)) in combination with other biomarkers (neuropsychological, genetics, plasma, serum, CSF, structural neuroimaging, 18F-FDG-PET) to predict clinical dementia onset

* To assess the diagnostic accuracy of amyloid agent Florbetapir (18F) and Flutemetamol (18F) to differentiate AD from other types of dementia (differential diagnosis)

* To study the link between amyloid binding agent and survivalstudy design

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
448
Inclusion Criteria
  • To be included in MEMENTO
  • To have signed a specific MEMENTO-AmyGing informed consent form, prior to any amyloid PET procedures
  • To have had or agreed to have 18F-FDG PET scan in MEMENTO
  • To tolerate the (18F) PET scan procedures, in the opinion of the clinical site investigator
  • Clinical Dementia Rating scale <0.5 and not demented
Exclusion Criteria
  • To have a current clinically significant psychiatric condition that neurologists/geriatricians feel would preclude the ability to have a research PET scan
  • To be pregnant or breastfeading women
  • To have Hypersensitivity to the tracer or to the excipient listed in the summary of the product carateristics (florbetapir Amyvid®) or the Investigator's Brochure (flutemetamol)
  • To have a relevant history of severe drug allergy or hypersensitivity (relevant severe drug allergies should be determined by the clinical site investigator or co-clinical site investigator). If a subject has a history of severe drug allergies, it may be dangerous for them to participate in a study with a novel compound
  • To have ever participated in an experimental study with an amyloid targeting agent (e.g. anti-amyloid immunotherapy, γ-secretase or γ-secretase inhibitor) unless it can be documented that the subject received only placebo during the course of the trial
  • To receive any investigational medications, or have participated in a trial with investigational medications within the last 30 days
  • To have participated less than 1 year ago in a biomedical research with injection of one of the amyloid radioligand or to be enrolled in an ongoing biomedical research including amyloid PET scan
  • To have had a radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Florbetapir (18F)Florbetapir (18F)-
Flutemetamol (18F)Flutemetamol (18F)-
Primary Outcome Measures
NameTimeMethod
Progression to clinical dementia stage according to standardized classifications (DSM-IV and NINCDS-ADRDA) as described in the MEMENTO protocol.24 months from baseline
Secondary Outcome Measures
NameTimeMethod
Longitudinal evolution of biomarkers measured from blood, CSF, structural neuroimaging (MRI) and glucose metabolism molecular neuroimaging (18F-FDG PET).24 months from baseline
Mortality24 months from baseline
Prodromal AD (Pre-symptomatic dementia)24 months from the baseline
Etiology of dementia, when converted24 months from the baseline
Longitudinal evolution of amyloid load measured through either Florbetapir (18F) or Flutemetamol (18F)24 months from baseline
Quality of life24 months from baseline
Speed of cognitive decline based on change in cognitive performances24 months from baseline
Loss of autonomy based on functional activity assessment24 months from baseline
Institutionalization24 months from baseline
Cardiovascular event (Stroke and Coronary events)24 months from baseline

Trial Locations

Locations (26)

CHU de Toulouse - Hôpital Purpan

🇫🇷

Toulouse, France

CHU de Bordeaux - Hôpital Xavier-Arnozan

🇫🇷

Bordeaux, France

CHU de Besançon

🇫🇷

Besancon, France

AP-HP - Avicenne

🇫🇷

Bobigny, France

CHU de Lille

🇫🇷

Lille, France

CHU de Grenoble

🇫🇷

Grenoble, France

CHU de Bordeaux - Pellegrin

🇫🇷

Bordeaux, France

CHU d'Angers

🇫🇷

Angers, France

CHU de Brest

🇫🇷

Brest, France

Hospices civils de Lyon

🇫🇷

Lyon, France

CHU de Clermont-Ferrand

🇫🇷

Clermont-ferrand, France

CHU de Nice

🇫🇷

Nice, France

AP-HM

🇫🇷

Marseille, France

CHU de Dijon

🇫🇷

Dijon, France

CHU de Nancy

🇫🇷

Nancy, France

CHU de Montpellier

🇫🇷

Montpellier, France

AP-HP - Hôpital BROCA

🇫🇷

Paris, France

CHU de Rouen

🇫🇷

Rouen, France

AP-HP - Hôpital LARIBOISIERE

🇫🇷

Paris, France

CHU de Poitiers

🇫🇷

Poitiers, France

CHU de Saint-Etienne - Hôpital de la charité

🇫🇷

Saint-etienne, France

CHU de Saint-Etienne - Hôpital Nord

🇫🇷

Saint-etienne, France

Ap-Hp La Pitié-Salpêtrière

🇫🇷

Paris, France

CHU de Strasbourg

🇫🇷

Strasbourg, France

CHU de Toulouse

🇫🇷

Toulouse, France

CHU de Tours

🇫🇷

Tours, France

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