itrous Oxide and Functional Magnetic Resonance Imaging to investigate cerebral regional blood flow, cerebral metabolism and neuronal activity. - Nitrous Oxide and Functional MRI
- Conditions
- This is part of a series of studies investigating the potential therapeutic use of low dose nitrous oxide in the treatment of cerebral vasospasm, a condition which occurs following brain injury and stroke. We are looking to see if the increased blood flow to the brain seen with nitrous oxide is caused by an increase in cerebral metabolism. This would need to be excluded if nitrous oxide is to be considered as a potential treatment.
- Registration Number
- EUCTR2009-018181-36-GB
- Lead Sponsor
- niversity of Nottingham
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Males and Females aged between 18 and 50
Are the trial subjects under 18?
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years)
F.1.3.1 Number of subjects for this age range
People with history or evidence of a systemic illness or vascular disease
On prescription medication which may affect cardiovascular system e.g. Beta blockers, Calcium channel antagonists
Cardiac pacemaker or mechanical heart valve
Implanted electrical devices e.g. hearing aid, nerve stimulator, cochlear implant, programmable shunt
Any evidence of neurological disorder including brain surgery, aneurysm clip
Smokers
Pregnant* or lactating females
Metal fragments in your eyes
Metal clips, pins, plates, implants, coils, screws, shrapnel or similar in your body
*In females pregnancy will be excluded by an hCG test within 24 hours preceding MRI scan
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method