Burn Micronutrient Repletion Pilot Study
- Conditions
- Burn
- Interventions
- Dietary Supplement: Vitamin and Mineral supplementation
- Registration Number
- NCT00879723
- Lead Sponsor
- Southern Illinois University
- Brief Summary
Burn injury patients undergo a series of metabolic changes that, if untreated, could lead to reduced health outcomes. Nutrition is thought to play a vital role in post-burn recovery. The research team developed a novel vitamin and mineral supplementation protocol based on current scientific literature. The study will test the hypothesis that the novel vitamin and mineral supplement regimen will improve adult patient recovery from burn injury.
- Detailed Description
Burn injury patients undergo a series of metabolic events that, if untreated, could lead to severe physical impairment and even death. Antioxidants minimize free radical damage by neutralizing the chemical reaction as well as promoting cellular repair. Currently there is no consistent protocol for micronutrient repletion in adult burn patients. The aim of this study is to evaluate the effectiveness of the current vitamin regimen in comparison to the novel vitamin and mineral supplementation protocol developed by the research team. Dosages for oral and intravenous supplementation are based on current literature. The combination of intravenous and enteral treatment is important due to gastrointestinal mucosal swelling related to post-burn fluid resuscitation. Measurable health outcomes will include rate of infection, length of hospital stay, mortality rate, hospital cost, number of days in intensive care unit, number of ventilator-dependent days and wound healing. The investigators hypothesize that use of the novel vitamin and mineral supplement regimen will improve adult burn patient outcomes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
- patients who present at the burn unit with TBSA > 1%
- less than 19 years old
- chronic renal failure
- chronic liver failure
- pregnancy or lactation
- patients who require parenteral nutrition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vitamin and mineral supplementation Vitamin and Mineral supplementation Intravenous micronutrient solution or an oral micronutrient supplementation twice per day for 14 days. Treatment is determined by percent total body surface area burned.
- Primary Outcome Measures
Name Time Method wound healing 14 days
- Secondary Outcome Measures
Name Time Method rate of infection 14 days number of days in hospital 14 days number of days on ventilator 14 days number of days in Intensive Care Unit 14 days mortality rate 14 days hospital charges 14 days
Trial Locations
- Locations (1)
Memorial Medical Center
🇺🇸Springfield, Illinois, United States