Bone Health in Hyperemesis Gravidarum

• Conditions: Hyperemesis Gravidarum

• Registration Number: NCT02862496
• Lead Sponsor: Kayseri Education and Research Hospital

Brief Summary

The purpose of the study is to determine whether maternal bone resorption would be seen in Hyperemesis Gravidarum and could be detected in early period using serum vitamin D levels, serum calcium (Ca) levels, serum parathormone (PTH) levels and urine N- telopeptide levels in the patients with Hyperemesis Gravidarum.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-07-21
• Status Verified: 2016-08
• Study First Submitted QC: 2016-08-07
• Last Update Submitted: 2016-08-07
• Study First Posted: 2016-08-11
• Last Update Posted: 2016-08-11
• Primary Completion: 2016-10
• Study Completion: 2016-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Between 7. and 20. weeks of gestation pregnant women in both groups
• İn hyperemesis group; 5% weight loss with regard to pre-gestation vomiting more than 3 times 3-5 % weight loss with ketonuria.

Exclusion Criteria

• Other pathologies that cause nausea and vomiting in pregnancy gastroenteritis gastroparesis gall duct diseases hepatitis peptic ulcers appendicitis pyelonephritis ovarian torsion urinary tract stones diabetic ketoacidosis hyperthyroidism hyperparathyroidism migraine pseudo tumor cerebra vestibular diseases
• Additionally some situations causing to rise of Ntx levels osteoporosis paget disease bone tumors
• Furthermore some of conditions resulted in pre-menopausal osteoporosis or decreasing in Bone Mineral Density Malignancy Smoking Celiac Disease Depression Inflammatory Bowel Disease Pre-gestational Diabetes Chronic Kidney or Liver Disease Drug Use such as steroids, anticonvulsants, antiepileptic, heparin or low molecular weight heparin

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Urine N- telopeptide levels in Pregnant Women with Hyperemesis Gravidarum	4 months
Serum Vitamin D Levels in Pregnant Women with Hyperemesis Gravidarum	4 months
Serum Calcium Levels in Pregnant Women with Hyperemesis Gravidarum	4 months
Serum Parathormone Levels in Pregnant Women with Hyperemesis Gravidarum	4 months

Trial Locations

Locations (1)

Kayseri Training and Research Hospital; 🇹🇷 Kayseri, Turkey