Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

Completed

• Conditions: Osteopenia; Osteoporosis
• Interventions: Other: No exercise; Other: resistance exercise; Other: plyometric exercise

• Registration Number: NCT00572871
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Detailed Description

Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Study Timeline

• Study Start: 2007-12
• Study First Submitted: 2007-12-12
• Study First Submitted QC: 2007-12-12
• Study First Posted: 2007-12-13
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-30
• Last Update Posted: 2016-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Male
• No symptoms of disease
• Non-sedentary
• Age 25-65

Exclusion Criteria

• Medications or supplements that affect bone metabolism or prevent exercise
• Previous or current medical condition affecting bone health, including osteoporosis.
• Cardiovascular disease
• Metallic implants affecting accuracy of bone density scan
• Current smoker
• Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No exercise	No exercise	Will complete a ten-hour fast but do no exercise
Exercise after fasting	resistance exercise	Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions after a 10-hour fast
Exercise after snack	plyometric exercise	Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions 2 hours following a 500 calorie nutritional supplement

Primary Outcome Measures

Name	Time	Method
serum bone turnover markers	24 hours

Secondary Outcome Measures

Name	Time	Method
serum hormones regulating bone turnover	24 hours