Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy

• Conditions: Trauma; Coagulopathy
• Interventions: Other: hypocalcemia

• Registration Number: NCT05530161
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.

Detailed Description

This 5-year retrospective, observational, single-center study was conducted at the Second Affiliated Hospital of Zhejiang University Medical School (SAHZU, China). Elderly patients with trauma were registered when they were admitted into intensive care unit affiliated to department of Emergency medicine (EICU) since January 2015 and September 2020.The purpose of this study is to elucidate the effect of hypocalcemia on TIC in elderly trauma patients through a single-center retrospective study, so as to further optimize the diagnosis and treatment strategies for TIC in elderly trauma patients.

Study Timeline

• Study Start: 2015-01-01
• Status Verified: 2022-08
• Study First Submitted: 2022-08-30
• Study First Submitted QC: 2022-09-06
• Last Update Submitted: 2022-09-06
• Study First Posted: 2022-09-07
• Last Update Posted: 2022-09-07
• Primary Completion: 2023-09-01
• Study Completion: 2023-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 371

Inclusion Criteria

• age≥65 years old
• history of trauma

Exclusion Criteria

• previous anticoagulants or antiplatelet medication;
• Coagulopathy caused by previous underlying diseases;
• Blood products transfused before admission;
• Cardiac arrest on admission;
• Malignant tumor;
• Data incomplete

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
trauma induced coagulopathy	hypocalcemia	patients with INR\>1.2

Primary Outcome Measures

Name	Time	Method
Internationalized Normalized Ratio (INR)	24 hour	coagulation function :Internationalized Normalized Ratio (INR)
Activated Partial Thromboplastin Time (APTT)	24 hour	coagulation function : Activated Partial Thromboplastin Time (APTT)
Prothrombin Time (PT)	24 hour	coagulation function : Prothrombin Time (PT)

Secondary Outcome Measures

Name	Time	Method
Blood products rate	through study completion, an average of 1 week	the rate of Blood products use

Trial Locations

Locations (1)

SAHZU; 🇨🇳 Hanzhou, Zhejiang, China