Comparison of Laparoscopic Partial Nephrectomy Versus Laparoscopic Radical Nephrectomy in Patients With High-Complexity Renal Tumors: A Propensity Score Matched Analysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Renal Cancer
- Sponsor
- Samsun Liv Hospital
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Postoperative complication
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The study aims to investigate the rationale for LPN in patients with high-complexity renal tumors in terms of oncologic and functional outcomes.
Detailed Description
From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and 265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus (DM), hypertension (HT), coronary artery disease (CAD), and final tumor pathology of RCC) was used to reduce selection bias. Functional and oncological outcomes were compared between the two groups. After propensity score analysis, 39 patients in the LRN group were matched with 39 in the LPN group.
Investigators
Mehmet Necmettin Mercimek
Principal Investigator
Samsun Liv Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients with complete data
- •Patients with single renal tumor on the effected side
- •Patients who approved the written consent form
Exclusion Criteria
- •Patients who not approved the written consent form
- •Patients with incomplete data
- •Patients with low or mild complexity renal tumors
Outcomes
Primary Outcomes
Postoperative complication
Time Frame: up to 3 months postoperatively
abnormal problmes that may be seen after surgery and require additional intervention, treatment or follow-up
functional outcomes
Time Frame: 1 year after the surgery
serum creatinine level (mg /dL) and estimated glomerular filtration rate (CKD Epidemiology Collaboration (CKD-EPI) equation) (mL/min/1.73 m2)
surigcal margin status
Time Frame: postoperative follow-up, through study completion, an average of 1 year
presence or absence of tumors at the surgical margin
CKD stage upgrading
Time Frame: postoperative follow-up, through study completion, an average of 1 year
evaluation of preoperative and postoperative renal functions according to chronic kidney disease stages
Oncological outomes
Time Frame: postoperative follow-up, through study completion, an average of 1 year
Presence or absence of local and/or distal tumor recurrence
Operation time
Time Frame: at the end of the surgery
time from onset to complete of surgery
Blood loss
Time Frame: at the end of the surgery
amount of bleeding during surgery (mL)
warm ischemia time
Time Frame: at the and of the surgery
The clamp time of the renal artery and vein which is required to complete tumor excision and renorrhaphy