The Effect of Menstrual Cycle on Periodontium
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- periodontal clinical parameters
研究概览
简要总结
Aim: Women's menstrual cycle is controlled by the secretion of sex hormones. Sex steroid hormones are thought to be affect to periodontal tissues, wound healing, periodontal disease progression and bone turn over. The aim the study is to evaluate clinical periodontal parameters and interleukin- 6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) in menstrual cycle.
Material and methods: Twenty-five patients were included in this study clinical periodontal parameters and levels of IL-6 and TNF α in gingival crevicular fluid were evaluated at three periods of menstrual cycle (menstruation day (MD)-ovulation day(OD)-premenstruation day (PmD)). Levels of IL-6 and TNF α in gingival crevicular fluid were determined by ELISA.
详细描述
Study Population
Sixty women were initially included in this longitudinal, prospective study in Yuzuncu Yil University, Faculty of Dentistry, Department of Periodontology.
The procedure was accepted and informed consent was signed by all participants. The material and method used in the trial were accepted by the Yuzuncu Yil University Ethics Committee and were found to conform to the guidelines issued in the Declaration of Helsinki. To standardize the effect of plaque accumulation on the tested parameters, subjects were given oral hygiene instructions before the study.
Clinical Procedures, and Measurements
All subjects were scheduled for periodontal measurements and GCF sampling on the specific days determined as follows: 1) menstruation day (MD); on days 2-3 of menstruation 2) ovulation day (OD); detected by saliva fertility microscope 12-14 days of menstrual cycle and 3) premenstruation day (PmD); 22-24 days of menstruation cycle.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 29 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Inclusion criteria were:
- •premenopausal women, age 20-35 to years;
- •normal and steady menstrual cycle (25 to 31 days long);
- •available for clinical examination;
- •non-smoking;
- •antibiotic therapy or use of nonsteroidal anti-inflammatory drugs within the past 6 months;
- •healthy systemic status;
- •normal body mass index;
- •healthy periodontium.
排除标准
- •Exclusion criteria were as follows:
- •use of oral contraceptives;
- •metabolic or systemic condition that might affect the periodontium;
- •antibiotic therapy or use of nonsteroidal anti-inflammatory drugs within the past 6 months;
- •periodontitis;
- •smoking and
- •with the diagnosis of polycystic over or hyperandrogenism according to Rotterdam diagnostic criteria
结局指标
主要结局
periodontal clinical parameters
时间窗: 1 menstrual cycle (approximately 1 month) every patient follow up
gingival index: according to Silness and Löe gingival index plaque index: according to Löe and Silness plaque index probing depth the distance between gingival margin to periodontal sulcus bottom (mm) IL-6 concentration (pg/microliter) TNF- alpha concentration (pg/microliter)
次要结局
未报告次要终点
研究者
Hacer Sahin Aydinyurt
assistant professor
Yuzuncu Yıl University