Influence of Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on the Muscle Protein Synthetic Response to Exercise in Young, Healthy Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change in Rates of Muscle Protein Synthesis
研究概览
简要总结
Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estrogen and progesterone) influence muscle mass and strength. Female physiology is unique in that hormones fluctuate throughout the menstrual cycle. In the first phase (follicular phase) following menstruation, estrogen levels are high while progesterone levels are low. In the second phase (luteal phase), progesterone levels are high. Females are often excluded from studies because researchers are concerned that the menstrual cycle might affect the results. The purpose of this study is to investigate the response to resistance exercise in each phase of the menstrual cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy females, between the ages of 18 and 30 y with a regular menstrual cycle
- •Body Mass Index between 18.5 and 30.0 kg/m2
- •Able and willing to provide informed consent
排除标准
- •A history of neuromuscular disorders or muscle/bone wasting diseases
- •Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin-dependent or insulin-independent diabetes, or the presence of any other metabolic disease - all of which will be determined via a medical history screening questionnaire
- •The use of any medications known to affect protein metabolism (glucocorticoids, non-steroidal anti-inflammatory medication, or prescription strength acne medication, etc.)
- •A (family) history of thrombosis
- •The use of anticoagulant medications
- •Consumption of tobacco-containing products
- •Excessive alcohol consumption (>21 units/wk)
- •History of bleeding diathesis, platelet or coagulation disorders
- •Currently pregnant
- •Irregular menstrual cycle as defined in the study protocol
结局指标
主要结局
Change in Rates of Muscle Protein Synthesis
时间窗: 6 days
The investigators will use deuterated water and skeletal muscle biopsies to calculate the synthesis of skeletal muscle proteins.
次要结局
- Whole-body proteolysis(6 days)
研究者
Stuart Phillips
Professor
McMaster University