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Clinical Trials/NCT06268678
NCT06268678
Completed
Not Applicable

The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis Following Protein Ingestion and Resistance Exercise in Young Women

University of Exeter1 site in 1 country14 target enrollmentDecember 8, 2023
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ConditionsMenstrual Cycle PhaseMuscle Protein Synthesis

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Menstrual Cycle Phase
Sponsor
University of Exeter
Enrollment
14
Locations
1
Primary Endpoint
Muscle protein synthesis
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been conducted exclusively in men or in studies where both men and women are assessed. The increase in muscle mass is thought to be impacted by sex hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis following exercise is not known.

Registry
clinicaltrials.gov
Start Date
December 8, 2023
End Date
September 28, 2024
Last Updated
last year
Study Type
Interventional
Study Design
Crossover
Sex
Female

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Female, aged 18-40 years
  • •BMI between 18 and 30 kg/m2
  • •Recreationally active
  • •Regular menstrual cycle

Exclusion Criteria

  • •Smoking or use of tobacco containing products
  • •Irregular menstrual cycle
  • •Currently on any form of hormonal contraception
  • •Post-menopausal
  • •Pregnant or breastfeeding
  • •Diagnosed metabolic/pulmonary/musculoskeletal illness
  • •Diagnosed cardiovascular disease or hypertension
  • •Use of medications that may impact protein metabolism or are anti-inflammatory
  • •Gastrointestinal disorders
  • •Allergy to pomegranate or amino acids

Outcomes

Primary Outcomes

Muscle protein synthesis

Time Frame: 7 hours

The rate of synthesis of new muscle protein

Secondary Outcomes

  • Plasma amino acid kinetics(7 hours)
  • Sex hormone concentrations(5 minutes)
  • Serum insulin concentrations(7 hours)
  • Energy expenditure(20 minutes)

Study Sites (1)

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