Brown Adipose Tissue Activity and Energy Metabolism in Cachexia Induced by Cancer or Chronic Disease

Maastricht University Medical Center1 个研究点分布在 1 个国家目标入组 16 人开始时间: 2015年6月1日最近更新: 2018年8月3日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: Maastricht University Medical Center
入组人数: 16
试验地点: 1
主要终点: Brown adipose tissue (BAT) activity measured by PET(-MRI)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.

详细描述

This is a prospective, cross-sectional study to determine BAT activity in cachectic patients with pancreatic or non-small cell lung cancer, and in cachectic patients with chronic obstructive pulmonary disease (COPD), and compare results with healthy individuals and non-cachectic COPD patients, matched for age and BMI.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Parallel
主要目的: Diagnostic
盲法: None

入排标准

年龄范围: 30 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Pancreatic cancer patients, or NSCLC cancer patients, or COPD patients
•The diagnostic criterion for cachexia is unintentional weight loss more than 5% over the past 6 months or more than 2% in individuals with a body-mass index < 20 kg/m2 and muscle wasting assessed by DXA;
•Age ≥ 30 years;
•Gender: male and female;
•Caucasians.

排除标准

•Uncontrolled Diabetes Mellitus;
•Patients with severe clotting disorder;
•Patients with an active second malignancy;
•Psychological unstable persons presumed unfit to perform the measurements, including claustrophobia;
•Persons unable to lie or sit still for 1-2 hours;
•Oxygen therapy;
•Pregnant subjects;Subjects unable to undergo MRI (e.g. pacemaker; neurostimulator; implantable cardioverter-defibrillator (ICD) or leads; Foley bladder catheter; medication pump; cochlear or hearing implant; tattoos or other items that cannot be removed and include metal parts (for instance from operations in the past); metal splinter in the eye; vascular clips; denture, which contains magnets);
•Subjects that received high doses of radiotherapeutic radiation of the neck and/or upper chest in their medical history;
•Persons that received cervical or thoracic sympathectomy or have a nerve dysfunction which is likely to influence sympathetic nerves;
•The use of medication that influences the sympathetic nerve system: ß-blockers, α-blockers, central anti-hypertensives, certain anti-depression drugs (MAO inhibitors, tricyclic anti-depressives), reserpine, cocaine, calciumblockers, labetalol, and certain tranquillizers (fenothiazines).

研究组 & 干预措施

Cachectic pancreatic cancer

Active Comparator

Cachectic patients with pancreatic cancer

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.