Mindfulness and Neural Cardiovascular Control in Humans
- Conditions
- Elevated Blood Pressure
- Interventions
- Behavioral: Stress Management
- Registration Number
- NCT03626363
- Lead Sponsor
- Michigan Technological University
- Brief Summary
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness. The investigator's central hypothesis is that MBSR will reduce sympathetic activity and arterial stiffness.
- Detailed Description
This study will recruit male and female subjects with elevated blood pressure who will participate in a randomized, active control study to examine the impact of mindfulness-based stress reduction (MBSR) on blood pressure, muscle sympathetic nerve activity and arterial stiffness. The study will utilize established techniques for assessing blood pressure patterns (24-hour ambulatory monitoring), peripheral sympathetic activity (microneurography) and vascular stiffness (applanation tonometry) in humans. This study includes a stress management education class for the active control.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
- Seated systolic blood pressure >119 mmHg and/or diastolic blood pressure >79 mmHg
- Body mass index <30 kg/m2
- Smokers
- Diabetes
- Pregnant women
- History of autonomic dysfunction
- Cardiovascular medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Mindfulness-Based Stress Reduction Stress Management - Stress Management Education Stress Management -
- Primary Outcome Measures
Name Time Method Muscle Sympathetic Nerve Activity Data reported is the change in the mean value from before to after the 8 week intervention (i.e. pre to post). Direct recordings of muscle sympathetic nerve activity from the peroneal nerve using microneurography. Sympathetic bursts that were at least three times higher than baseline noise were evaluated by a trained investigator and quantified as bursts per minute. The investigator was blinded to the condition and whether the data was pre or post until after all data was collected and analyzed.
- Secondary Outcome Measures
Name Time Method Arterial Stiffness Data reported is the change in the mean value from before to after the 8 week intervention (i.e. pre to post). Carotid-femoral pulse wave velocity using applanation tonometry. A SphygmoCor system was used to gait pulse waves from a tonometer to the R-wave of a 3-lead ECG and carotid to femoral pulse wave velocity was evaluated in meters per second. A higher value indicates more arterial stiffness in the aorta, and a lower value indicates less stiffness in the aorta.
Trial Locations
- Locations (1)
Purdue University Northwest
🇺🇸Hammond, Indiana, United States