An adipocyte-driven mechanism for weight regain after weight loss: the yo-yo effect

• Conditions: obesity; 10003018; adiposity

• Registration Number: NL-OMON37833
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 58

Inclusion Criteria

healthy volunteers aged 20-65 y, BMI 28-35 kg/m2, non-smokers

Exclusion Criteria

Subjects using prescription medication, or suffering from diseases or conditions that might influence the outcome of the study: this concerns diseases/medication that influence body weight regulation (malabsorption, untreated hypo/hyperthyroidism, eating disorders, systemic use of steroids, etc.) and obesity-related cardiovascular risk factors (heart disease, systolic and diastolic blood pressures > 160/100 mmHg, blood glucose > 6.1 mmol L-1, blood cholesterol > 7 mmol L-1, blood triglycerides > 3 mmol L-1), marked alcohol consumption > 21 alcoholic units week-1 (male), or >14 alcoholic units week-1 (female), planned major changes in physical activity during the study to an extent that might interfere with the study outcome, as judged by the investigator; blood donation within the past 2 months prior to the study; weight change of >3 kg within 2 months prior to the study; psychiatric disease (based on medical history only); pregnant or lactating women, or women planning to become pregnant within the next 12 months; surgically treated obesity; participation in other clinical studies within the last 3 months; drug abuse (based on clinical judgment); unable to give informed consent; unable to engage in a low-calorie diet; following a special diet (e.g. Atkins).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The association between the amount of weight regain after the weight loss<br /><br>period and changes in adipokines, parameters of adipocyte metabolism, in vivo<br /><br>adipose tissue metabolism, adipocyte extracellular matrix gene expression<br /><br>profiles, adipocyte stress protein expression and gene polymorphisms in<br /><br>selected genes. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The difference in weight regain and associated parameters between rapid and<br /><br>slow weight loss regimens.</p><br>