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临床试验/NCT06593067
NCT06593067已完成不适用

Skin Surface and Intradermal Temperature Responses to Heat Stress

University of Texas Southwestern Medical Center1 个研究点 分布在 1 个国家目标入组 27 人开始时间: 2024年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
27
试验地点
1
主要终点
Skin Temperature With Fan Only

研究概览

简要总结

The purpose of this study is to compare surface and intradermal skin temperature responses to heat stress with and without evaporative and convective cooling.

详细描述

Humans have important thermoregulatory responses aimed at maintaining body temperature within a narrow range. These responses are driven in part by receptors located in the skin that monitor temperature changes and provide feedback to the central nervous system. Given that skin temperature can affect the physiological responses to heat stress, it is important to accurately measure skin temperature in response to heat stress with and without evaporative (i.e., sweat) and convective (i.e., air flow) cooling. Skin temperature is most often measured on the surface of the skin; however, this temperature can be influenced by other factors such as the local environment. It is unclear how the temperature of the skins surface compares to the temperature within the dermal layer of the skin.

The study team will directly compare skin surface and intradermal temperature responses to heat stress and determine whether these responses area altered by evaporative or convective cooling methods. To accomplish this objective, healthy adults will be exposed to ambient heat stress (no higher than 47°C) with and without evaporative (water sprayed on the skin) and convective (electric fan) cooling. Thermoregulatory responses, inclusive of skin surface and intradermal temperatures, will be assessed throughout the heat trial.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Free of any significant underlying medical problems based upon a detailed medical history and physical exam.
  • •Normal resting electrocardiogram.

排除标准

  • •Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc.; as well as serious abnormalities detected on routine screening.
  • •Individuals who are pregnant, planning to become pregnant, or breastfeeding.
  • •Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.
  • •Current smokers, as well as individuals who regularly smoked within the past 3 years.

研究组 & 干预措施

Skin Temperature Thermocouple on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using a standard temperature probe

干预措施: Water Spray (Other)

Intradermal Skin Temperature Needle in Intradermal Skin Layer

Active Comparator

Skin temperature measured in the intradermal space

干预措施: Control (Other)

Intradermal Skin Temperature Needle on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using the same type of probe as that used in the intradermal space.

干预措施: Control (Other)

Intradermal Skin Temperature Needle in Intradermal Skin Layer

Active Comparator

Skin temperature measured in the intradermal space

干预措施: Fan (Other)

Intradermal Skin Temperature Needle in Intradermal Skin Layer

Active Comparator

Skin temperature measured in the intradermal space

干预措施: Fan and Water Spray (Other)

Intradermal Skin Temperature Needle on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using the same type of probe as that used in the intradermal space.

干预措施: Fan (Other)

Intradermal Skin Temperature Needle on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using the same type of probe as that used in the intradermal space.

干预措施: Fan and Water Spray (Other)

Skin Temperature Thermocouple on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using a standard temperature probe

干预措施: Control (Other)

Skin Temperature Thermocouple on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using a standard temperature probe

干预措施: Fan (Other)

Skin Temperature Thermocouple on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using a standard temperature probe

干预措施: Fan and Water Spray (Other)

Intradermal Skin Temperature Needle in Intradermal Skin Layer

Active Comparator

Skin temperature measured in the intradermal space

干预措施: Water Spray (Other)

Intradermal Skin Temperature Needle on Skin Surface

Active Comparator

Skin temperature measured on the skin's surface using the same type of probe as that used in the intradermal space.

干预措施: Water Spray (Other)

结局指标

主要结局

Skin Temperature With Fan Only

时间窗: 40 minutes into the heat intervention.

Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with the fan cooling modality.

Skin Temperature With Fan and Water Spray

时间窗: 60 minutes into the heat intervention.

Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with both the fan and water spray cooling modalities.

Skin Temperature With Water Spray Only

时间窗: 1 hour 20 minutes into the the heat intervention.

Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with the water spray cooling modality.

Skin Temperature With No Cooling

时间窗: 20 minutes into the heat intervention.

Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant during the heat intervention with no cooling.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Craig Crandall

Professor of Internal Medicine

University of Texas Southwestern Medical Center

研究点 (1)

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