Exploration of the Possibility That Local Injury of the Endometrium Has the Same Beneficial Effect on IUI Outcome as Demonstrated in IVF Treatment
试验速览
- 阶段
- 不适用
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Clinical Pregnancy rate
研究概览
简要总结
It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy. The hypothesis of our present study is that the endometrial injury procedure will have the same beneficial effect in patients undergoing controlled ovarian hyperstimulation (COH) combined with intrauterine insemination (IUI).
详细描述
In order to test our hypothesis, we will perform the simple procedure of local injury of the endometrium using a "Pipelle" biopsy catheter during the spontaneous menstrual cycle that precedes a COH + IUI treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •infertility.
- •patients undergoing IUI treatment.
- •at least one failed IUI cycle.
排除标准
- •indication for IVF treatment.
- •Known Pelvic inflammatory disease(PID).
研究组 & 干预措施
Clomiphene citrate + IUI + endometrial biopsy
Clomiphene citrate + IUI + endometrial biopsy
干预措施: endometrial biopsy (Procedure)
Clomiphene citrate + IUI
gonadotrophines + IUI + endometrial biopsy
two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment.
干预措施: endometrial biopsy (Procedure)
gonadotrophines + IUI
natural cycle + IUI + endometrail biopsy
two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment.
干预措施: natural cycle + IUI + endometrial biopsy (Procedure)
natural cycle + IUI
结局指标
主要结局
Clinical Pregnancy rate
时间窗: 1 year
次要结局
- Live birth(2 years)