High-intensity Exercise Training in Patients With Post-infarction Heart Failure

Not Applicable

Completed

• Conditions: Heart Failure; Myocardial Infarction
• Interventions: Behavioral: Moderate intensity exercise training; Behavioral: High intensity exercise training

• Registration Number: NCT00218933
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. However attenuation of left ventricular (LV) remodelling has been documented in some studies. The effects of high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study.

Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.

Detailed Description

Not available

Study Timeline

• Study Start: 2001-10
• Primary Completion: 2005-09
• Study Completion: 2005-09
• Study First Submitted: 2005-09-20
• Study First Submitted QC: 2005-09-20
• Study First Posted: 2005-09-22
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-07
• Last Update Posted: 2017-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

Post-infarction heart failure and optimal treatment (ACE-inhibitors, Beta-blockade)

Exclusion Criteria

Not able to walk on a treadmill, unstable angina, participating in another experiment, serious arrhythmia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
moderate exercise training	Moderate intensity exercise training	-
high intensity exercise training	High intensity exercise training	-

Primary Outcome Measures

Name	Time	Method
Remodelling of heart function and structure	3 months

Secondary Outcome Measures

Name	Time	Method
Improved endothelial and skeletal muscle as well as quality of life	3 months

Trial Locations

Locations (1)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway