ARA290 and the ventilatory response to hypoxia and pain responses in healthy volunteers.

Recruiting

• Conditions: Hypoxia; Hypoxic Ventilatory Response.; Hypoxic Pulmonary Vasoconstriction

• Registration Number: NL-OMON23515
• Lead Sponsor: eiden University Medical Center (LUMC)

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

The major inclusion criteria is that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.

Exclusion Criteria

1. Obesity (BMI > 35);

2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia);

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Hypoxic Ventilatory Response (HVR);<br /><br>2. Pulmonary Artery Pressure (PAP).

Secondary Outcome Measures

Name	Time	Method
1. Systolic and diastolic cardiac functions;<br /><br>2. Vital and ventilatory parameters;<br /><br>3. Pain thresholds under hypoxia.