A comparison of Dual triggering by administration of GnRH agonist plus HCG versus HCG in poor responders in ART outcomes

Not Applicable

Conditions: Infertility.
Female infertility of other origin
N97.8

Registration Number: IRCT2016111628756N4

Lead Sponsor: shahid saoughi university of medical science

Brief Summary: Abstract Background The use of dual triggering in high and normal responders accompanied with better IVF cycle outcomes. Also, it has been suggested that dual triggering in poor responders can be accompanied by better results. Objective The aim of present study was to evaluate whether the Dual trigger, can improve oocyte maturation in poor responder patients based on Bologna criteria and their ART outcomes. Materials and methods All poor ovarian responder's patients underwent GnRH antagonist controlled ovarian hyperstimulation protocols in ART cycles. The participants' randomizations were done and patients divided into two groups. In the first group, final oocyte maturation was done by 6500 I.U.HCG alone. In the second group, triggering was done with coadministration of 6500 I.U.HCG plus 0.2?mg triptorelin simultaneous (dual trigger). Oocyte retrieval was performed 36?h after triggering through transvaginal ultrasound-guided. Routine IVF/ICSI was performed as appropriate. Results The number of retrieved oocytes, number of mature oocytes (MII), number of fertilized oocytes (2PN), number of embryo formation, number of transferred embryos and embryo quality have not significant differences between the two groups (p?>?0.05). Also, fertilization and implantation rate, chemical and clinical pregnancy did not differ between groups. Conclusion Dual triggering for final oocyte maturation in poor ovarian responders did not improve the number of mature oocytes (MII) and other ART cycle results.

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 82

Inclusion Criteria

poor ovarian responders women (based on Bologna criteria)
GnRH antagonist protocols
fresh embryo transfer

Exclusion Criteria

endometrial polyps
presence of endocrine disorders (such as hyperprolactinemia, hypothyroidism)
preimplantation genetic diagnosis cycles
non fresh embryo transfer cycles.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of metaphase II oocytes. Timepoint: After intervention. Method of measurement: number.

Secondary Outcome Measures

Name	Time	Method
umber of fertilized oocytes (2PN). Timepoint: after intervention. Method of measurement: number.;Clinical pregnancy. Timepoint: 28 days after transfer. Method of measurement: 28 days after transfer.