Coronary Artery Disease (CAD) in Patients HIV-infected
- Conditions
- HIV Infections
- Registration Number
- NCT04579146
- Lead Sponsor
- Hôpital Européen Marseille
- Brief Summary
HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a substantial proportion of obstructive CAD. Degree of stenosis is associated with immunoactivation (lymphocyte and monocyte) and microbial translocation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
HIV-infected patients >= 45 years with 2 or more CV risk factors currently on ART HIV-RNA < 50 copies >= 12 months (one blip allowed) Asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) Stable ART for more than 6 months
Exclusion Criteria
- Sign of coronary pathology (chest pain, syncope, dyspnea).
- ATCD of allergy to IV contrast agents
- Chronic inflammatory disease other than HIV
- Subject to a measure for the protection of justice
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method correlation between a particular profile of immune activation in patients HIV under treatment presenting cardiovascular risk factors and the presence of coronary atheromatous plaques 24 months Assessment of the prevalence of obstructive coronary artery disease in patients infected with HIV and asymptomatic with a 64-slice CT coronary angiography.
- Secondary Outcome Measures
Name Time Method Identify the bacterial populations constituting the intestinal microbiota in patients infected with HIV and look for a microbiotic signature in patients with subclinical atherothrombosis. 24 months microbial translocation (16S DNA)
Trial Locations
- Locations (1)
BENNANI
🇫🇷Marseille, France
BENNANI🇫🇷Marseille, France