Role of Levocarnitine supplementation on recovery in children with Complicated Severe Acute Malnutritio
Phase 3
- Conditions
- Health Condition 1: E43- Unspecified severe protein-caloriemalnutrition
- Registration Number
- CTRI/2022/10/046683
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All children 6 months-5 years fulfilling the WHO criteria for complicated severe acute malnutrition will be included. Complicated severe acute malnutrition is defined as children with clinical features of infection, severe anemia, metabolic disturbances, edema, hypothermia, vomiting, severe dehydration or a lack of apetitie
Exclusion Criteria
1. Children with congenital heart disease and acquired heart disease
2. Children with chronic organ dysfunction
3. Children with congenital malformations
4. Children with chromosomal anomalies
5. Children with inborn errors of metabolism
6. Children already taking levocarnitine supplementation will be excluded
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of children with weight for height more than -2 Z ScoreTimepoint: 6 months after intervention
- Secondary Outcome Measures
Name Time Method 1. Time to Recovery <br/ ><br>2. Duration of Hospital Stay <br/ ><br>3. Mortality <br/ ><br>4. Brain Natriuretic Peptide, Creatinine Kinase MB and CTrop I <br/ ><br>5. Left ventricular Mass, left ventricular mass index, ejection fraction and fractional shortening <br/ ><br>6. Relapse rateTimepoint: 3 months and 6 months <br/ ><br>3 months and 6 months <br/ ><br>3 months and 6 months