Assessing effect of L-carnitine supplementation on nutritional status, serum inflammatory and oxidative stress factors, matrix metalloproteinase enzymes and clinical symptoms of females with knee osteoarthritis
- Conditions
- knee osteoarthritis.Bilateral primary osteoarthritis of knee
- Registration Number
- IRCT201311231197N17
- Lead Sponsor
- Vice Chancellor for research of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 72
Female; Age: 40-60 years; Bilateral primary osteoarthritis of knee (according to ACR classification); Body mass index of 25-35; Using glucoseamine & chondrotin sulphate supplements and acetaminophene as anti-pain drug; Patient tendency and ability to participate in the study. Exclusion criteria: Severe osteoarthritis; Secondary osteoarthritis; Active synovitis; Having a history of knee injection during the past 6 months; Neurological disorder that affects movement, muscle control and balance; Uncontrolled hypertension, diabetes, cardiovascular disorders, chronic kidney disorders and functional liver disorders; Using Furosemide, Probenecid, Anticoagulants, Anticonvulsant, Sulphonamides, Methotrexate, Lithium salts and muscle relaxants; Using antioxidant supplements and w3; Smoking; History of allergy; Pregnancy and or lactation.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: WOMAC questionnaire.;Joint stiffness. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: WOMAC questionnaire.;Diability. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: WOMAC questionnaire.
- Secondary Outcome Measures
Name Time Method Serum inflammatory factors. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: IL-1ß and hs-CRP.;Serum oxidative factors. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Malondialdehide and total antioxidant capacity.;Serum matrix metalloproteinases. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: matrix metalloproteinase-1 and matrix metalloproteinase-13.;Nutritional status and dietary intake. Timepoint: Before the intervention and 2 months after the intervention. Method of measurement: Dietary intake: 24 hours food recall questionnaire; Nutritional status: Weight: Standard scale, Height: Stadiometer.