NL-OMON43616CompletedPhase 4
DD-study: diet or diuretics for salt-sensitivity in chronic kidney disease - DD-Study
Erasmus MC, Universitair Medisch Centrum Rotterdam0 sites22 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Enrollment
- 22
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Age > 18 years.
- •- Chronic kidney disease stage 3 or 4 (MDRD-GFR 15-60 ml/min)
- •- Use of any anti-hypertensive drugs
- •- No anti-hypertensive drugs but an average office systolic blood pressure > 140 mmHg (as measured by datascope)
Exclusion Criteria
- •- Salt-wasting chronic kidney disease
- •- Nephrotic syndrome
- •- Pregnant or breastfeeding women
- •- Life expectancy < 6 months
- •- Severe heart failure (NYHA III or IV) or liver cirrhosis with ascites and the inability to withdraw diuretics
- •- Rapidly declining kidney function with high likelihood of dialysis or kidney transplantation in the coming 4 months
- •- Kidney transplant recipients
- •- Use of immunosuppressive drugs
- •- Use of non-steroidal anti-inflammatory drugs
- •- Previous intolerance or allergy to hydrochlorothiazide or amiloride
- •- Serum sodium < 135 mmol/l
- •- Serum potassium < 3.5 mmol/l or > 5.0 mmol/l
- •- Inability to adhere to the study protocol (due to language, incapacitated subjects, subjects with intellectual disability)
Investigators
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